AUTHOR: SEOK WOO YANG, MD & PhD.

CONTACT: Email: soplab@outlook.kr

DATE: 2020.04.07

CONTENT:

 

 As of 7th April, in a small city with approximately 160,000 citizens, the confirmed COVID-19 + cases are 50. The mortality rate is 0.

 

 The patients in my clinic were mainly those with respiratory diseases. There have been no confirmed COVID-19 cases.

 

 Some patients had fevers. With the therapeutic strategy in line with several previous posts, there have been no confirmed cases of COVID-19 yet. Even several patients with fevers and bronchitis who dropped out of screening hospitals concerning COVID-19 without testing recovered without the aggravation of respiratory diseases. About the reason why they were dropped out of COVID-19 test even with fevers, has not it known.

 

 The therapeutic drugs administered did NOT include hydroxychloroquine and azithromycin.

 

 The taken home message is that primary care in the early phase of respiratory diseases amid COVID-19 contagion is a key factor to a key factor to prevent the patients from being vulnerable to COVID-19.

 

 Early diagnosis, Early treatment!

 

P.S.

 In some patients with neurologic signs, including headache, alteration of smell and taste and oral mucosa, acyclovir was prescribed simultaneously as I posted.

Virus Natural product(s) evaluated Proposed mechanism(s)
Coronavirus

Saikosaponin (A, B2, C, D) against HCoV-22E9

Lycoris radiata and its active component

lycorine, Artemisia annua, Pyrrosia lingua, and Lindera aggregata against SARS-CoV

Phenolic compounds of Isatis indigotica against SARS-CoV

Amentoflavone isolated from Torreya nucifera against SARS-CoV

Myricetin and scutellarein against SARS-CoV

Houttuynia cordata water extract against SARS-CoV

Saikosaponin B2 inhibits viral attachment and penetration stages

Unclear

 

SARS-CoV 3CL protease inhibitor

 

SARS-CoV 3CL protease inhibitor

 

SARS-CoV helicase inhibitor

 

SARS-CoV 3CL protease inhibitor; viral polymerase inhibitor

 

 

Reference

Lin LT, Hsu WC, Lin CC. Antiviral Natural Products and Herbal Medicines. J Tradit Complement Med. 2014 Jan-Mar; 4(1):24-35

 

 

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