SUMMARIZER: SEOK WOO YANG, MD & PhD (E.mail: soplab@outlook.kr)

DATE: 2020.03.10

THEME REFERENCE PDF file download

Molecular Pathology

(acute respiratory distress syndrome)

Gralinski LE, Baric RS. Molecular pathology of emerging coronavirus

infections. Version 2. J Pathol. 2015 Jan;235(2):185-95.

 PDF free for use.

An Overview of Their Replication and Pathogenesis

 Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015;1282:1–23. PDF free for use.
Virus-Host Interactions Lim YX, Ng YL, Tam JP, Liu DX. Human Coronaviruses: A Review of Virus-Host Interactions. Diseases. 2016;4(3):26. PDF free for use.

Anatomic Pathology of SARS

(including central nervous system and adrenal gland)

Pathology and Pathogenesis of Severe Acute Respiratory Syndrome

Jiang Gu, Christine Korteweg

Am J Pathol. 2007 Apr; 170(4): 1136–1147.

 PDF free for use.
Renal Pathology Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Chu, Kwok Hong et al.

Kidney International, Volume 67, Issue 2, 698 - 705

 PDF free for use.
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AUTHOR: SEOK WOO YANG, MD & PhD (E mail: soplab@outlook.kr)

DATE:2020.03.09

CONTENT:

 

ORGAN ANATOMIC PATHOLOGIC FINDINGS CLINICAL IMPLICATION
Lung

Diffuse alveolar damage.

Desquamation of pneumocytes.

Hyaline membrane disease.

Intra-alveolar fibromyxoid exudate.

Pulmonary edema.

Interstitial mononuclear cell infiltration, predominantly lymphocytes.

Multinucleated syncytial cells with atypical enlarged pneumocytes characterised by large nuclei, amphophilic granular cytoplasm, and prominent nucleoli.[1]

 

Acute respiratory distress syndrome.

Acute lung injury.
Heart Interstitial mononuclear inflammatory infiltrates  
Liver

Moderate microvesicular steatosis.

Mild lobular and portal activity.[1]

  
Kidney in COVID-19

No datum.

  
Kidney in MERS-CoV

Acute kidney injury.

Tubular epithelial cell degnerative/regenerative change.[2]

 Kidney failure.
Central nervous system in COVID-19 No datum.  
Central nervous system in SARS-CoV Viral particles rich in brain neurons.[3] A potential neuroinvasion

 

REFERENCE:

[1] Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, Tai Y, Bai C, Gao T, Song J, Xia P, Dong J, Zhao J, Wang FS. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020 Feb 18:S2213-2600(20)30076-X

[2] Alsaad KO, Hajeer AH, Al Balwi M, Al Moaiqel M, Al Oudah N, Al Ajlan A, AlJohani S, Alsolamy S, Gmati GE, Balkhy H, Al-Jahdali HH, Baharoon SA, Arabi YM. Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV)
infection - clinicopathological and ultrastructural study. Histopathology. 2018 Feb;72(3):516-524.

[3] Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients. J Med Virol. 2020 Feb 27.

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