AUTHOR: SEOK WOO YANG, MD & PhD (E mail: soplab@outlook.kr)
DATE:2020.03.09
CONTENT:
| ORGAN | ANATOMIC PATHOLOGIC FINDINGS | CLINICAL IMPLICATION |
| Lung |
Diffuse alveolar damage. Desquamation of pneumocytes. Hyaline membrane disease. Intra-alveolar fibromyxoid exudate. Pulmonary edema. Interstitial mononuclear cell infiltration, predominantly lymphocytes. Multinucleated syncytial cells with atypical enlarged pneumocytes characterised by large nuclei, amphophilic granular cytoplasm, and prominent nucleoli.[1]
|
Acute respiratory distress syndrome. Acute lung injury. |
| Heart | Interstitial mononuclear inflammatory infiltrates | |
| Liver |
Moderate microvesicular steatosis. Mild lobular and portal activity.[1] |
|
| Kidney in COVID-19 |
No datum. |
|
| Kidney in MERS-CoV |
Acute kidney injury. Tubular epithelial cell degnerative/regenerative change.[2] |
Kidney failure. |
| Central nervous system in COVID-19 | No datum. | |
| Central nervous system in SARS-CoV | Viral particles rich in brain neurons.[3] | A potential neuroinvasion |
REFERENCE:
[1] Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, Tai Y, Bai C, Gao T, Song J, Xia P, Dong J, Zhao J, Wang FS. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020 Feb 18:S2213-2600(20)30076-X
[2] Alsaad KO, Hajeer AH, Al Balwi M, Al Moaiqel M, Al Oudah N, Al Ajlan A, AlJohani S, Alsolamy S, Gmati GE, Balkhy H, Al-Jahdali HH, Baharoon SA, Arabi YM. Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV)
infection - clinicopathological and ultrastructural study. Histopathology. 2018 Feb;72(3):516-524.
[3] Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients. J Med Virol. 2020 Feb 27.